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Published TCIMAIL newest issue No.198
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CAS RN: 1134-47-0 | Product Number: B3343
Baclofen
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Purity: >98.0%(T)
Synonyms:
- 4-Amino-3-(4-chlorophenyl)butyric Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
€21.00
|
2 | 5 |
| 5G |
€68.00
|
3 | 14 |
| 25G |
€214.00
|
2 | 6 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B3343 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__0H__1__2ClNO__2 = 213.66 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1134-47-0 |
| Reaxys Registry Number | 2104494 |
| PubChem Substance ID | 87561134 |
| Merck Index (14) | 937 |
| MDL Number | MFCD00055143 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 208 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 214-486-9 |
| RTECS# | MW5084200 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2922498590 |
Application
Baclofen: A γ-Amino Butyric Acid Type B (GABAB) Receptor Agonist
Baclofen is a γ-amino butyric acid type B (GABAB) receptor agonist. Baclofen is a muscle relaxant and antispastic, but the precise mechanism of action of baclofen is not fully understood. However, baclofen is a structural analog of the inhibitory neurotransmitter GABA, and may exert its effects by stimulating of the GABAB receptor subtype. Current studies suggest that baclofen may reduce alcohol dependence. Baclofen is a racemic compound, and its active enantiomer is (R)-Baclofen (l-baclofen or STX209) [B5102]. (The product is for research purpose only.)
References
- Baclofen. Preliminary report of its pharmacological properties and therapeutic efficacy in spasticity (a review)
- (-)-Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor
- A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system (a review)
- Baclofen: a new drug for the treatment of alcohol dependence (a review)
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