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Published TCIMAIL newest issue No.201
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CAS RN: 69308-37-8 | Product Number: B5102
(R)-Baclofen
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Purity: >95.0%(T)(HPLC)
Synonyms:
- (R)-4-Amino-3-(4-chlorophenyl)butyric Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 25MG |
58,00 €
|
Contact Us | Contact Us | |
| 100MG |
170,00 €
|
Contact Us | Contact Us |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | B5102 |
Purity / Analysis Method 
|
>95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__2ClNO__2 = 213.66 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 69308-37-8 |
| Reaxys Registry Number | 4783400 |
| PubChem Substance ID | 354333943 |
| MDL Number | MFCD01321057 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation [a]20/D | 7.0 to 8.0 deg(C=1.6mol/L HCL) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 176 °C(dec.) |
| Specific Rotation | 7° (C=1,6mol/L HCl) |
| Solubility (insoluble in) | Methanol, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| RTECS# | DA8339450 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2922498590 |
Application
(R)-Baclofen: The Active Enantiomer of a GABAB Receptor Agonist, Baclofen
(R)-Baclofen (l-baclofen or STX209) is the more active enantiomer of racemic baclofen [B3343] which is a γ-amino butyric acid type B (GABAB) receptor agonist. Baclofen is a muscle relaxant and antispastic, but the precise mechanism of action of baclofen is not fully understood. However, baclofen is a structural analog of the inhibitory neurotransmitter GABA, and may exert its effects by stimulating of the GABAB receptor subtype. (The product is for research purpose only.)
References
- The biological activity of d- and l-baclofen (Lioresal®)
- 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain
- Metabolic and pharmacokinetic differentiation of STX209 and racemic baclofen in humans
- ACS Chemical Neuroscience Molecule Spotlight on STX209 (Arbaclofen) (a review)
PubMed Literature
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