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Published TCIMAIL newest issue No.198
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CAS RN: 96187-53-0 | Product Number: B5707
Brequinar
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Purity: >98.0%(HPLC)
Synonyms:
- 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 20MG |
€74.00
|
Contact Us | 27 |
| 100MG |
€238.00
|
Contact Us | 15 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B5707 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__1__5F__2NO__2 = 375.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 96187-53-0 |
| Reaxys Registry Number | 8354757 |
| PubChem Substance ID | 468590664 |
| MDL Number | MFCD00866437 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 3.50 to 4.00 % |
Properties (reference)
| Melting Point | 317 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933499090 |
Application
Brequinar: An Inhibitor of Dihydroorotate Dehydrogenase (DHODH)
Brequinar is a synthetic quinolinecarboxylic acid analogue with antineoplastic and immunosuppressive properties. Brequinar reportedly inhibits the enzyme dihydroorotate dehydrogenase (DHODH) which is catalyzes the conversion of dihydroorotate (DHO) to orotate, the fourth reaction of pyrimidine de novo synthesis. (The product is for research purpose only.)
References
- Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives
- Multiple Inhibitor Analysis of the Brequinar and Leflunomide Binding Sites on Human Dihydroorotate Dehydrogenase
- Characterization of dengue virus resistance to brequinar in cell culture
- Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) inhibitors (a review)
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