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Published TCIMAIL newest issue No.198
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CAS RN: 61-75-6 | Product Number: B6544
Bretylium Tosylate
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- N-(2-Bromobenzyl)-N,N-dimethylethanaminium 4-Methylbenzenesulfonate
- (o-Bromobenzyl)ethyldimethylammonium p-Toluenesulfonate
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 25MG |
€185.00
|
Contact Us | 20 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B6544 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__8H__2__4BrNO__3S = 414.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 61-75-6 |
| Reaxys Registry Number | 5704709 |
| MDL Number | MFCD00038731 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 60.0 to 64.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 62 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 200-516-8 |
| RTECS# | BO9450000 |
Transport Information:
| HS Number | 2923900090 |
Application
Bretylium Tosylate: A Class III Antiarrhythmic Agent
Bretylium tosylate is a class III antiarrhythmic agent with prominent experimental and clinical antifibrillatory activity. Its antiarrhythmic action is significantly different from that of other antiarrhythmic agents. It is an adrenergic neuron blocker that is selectively absorbed at peripheral adrenergic nerve terminals where it first releases norepinephrine [A0906] (sympathomimetic effect) and then produces adrenergic neuron blockade. It also acts by blocking K+ channels and is classified as a class III antiarrhythmic. (The product is for research purpose only.)
Reference
- Bretylium tosylate: a newly available antiarrhythmic drug for ventricular arrhythmias (a review)
- Bretylium tosylate: profile of the only available class III antiarrhythmic agent (a review)
- Potentially significant drug interactions of class III antiarrhythmic drugs (a review)
- Bretylium tosylate (A review on the description, physical properties, synthesis, analysis, stability, absorption, metabolism, and excretion.)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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