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Published TCIMAIL newest issue No.199
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CAS RN: 54-05-7 | Product Number: C3730
Chloroquine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N4-(7-Chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 250MG |
€36.00
|
Contact Us | ≥80 |
| 1G |
€108.00
|
3 | 15 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C3730 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__6ClN__3 = 319.88 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 54-05-7 |
| Reaxys Registry Number | 482809 |
| PubChem Substance ID | 468591247 |
| Merck Index (14) | 2163 |
| MDL Number | MFCD00024009 |
Specifications
| Appearance | White to Light yellow powder to lump |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 89.0 to 93.0 °C |
| Specific rotation | -1.0 to +1.0 deg (C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 91 °C |
| Maximum Absorption Wavelength | 228 nm (H__2O) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 200-191-2 |
| RTECS# | VB2360000 |
Transport Information:
| HS Number | 2933499090 |
Application
Exosome research
References
- Interfering with endolysosomal trafficking enhances release of bioactive exosomes
Application
Chloroquine: A Derivative of 4-Aminoquinoline with Autophagy Inhibitory, Antimalarial and Anticancer Activities
Chloroquine is a derivative of 4-aminoquinoline, which is an inhibitor of autophagy and has antimalarial and anticancer activities.1-3) In addition, chloroquine has been also reported to exert anti-corona viral activity, including anti-SARS-CoV-2, in vitro.4-6) The mechanism of action of chloroquine is not completely understood. But, some studies have demonstrated that chloroquine is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. In addition, while chloroquine can inhibit certain enzymes, its effect is believed to result, at least in part from its interaction with DNA. (The product is for research purpose only.)
References
- 1) Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
- 2) Antimalarial Agents: Chloroquine, Hydroxychloroquine, and Quinacrine (a review)
- 3) Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells
- 4) In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine
- 5) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
- 6) Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection
- 7) Chloroquine phosphate (a review on the physical properties, synthesis, metabolites, and methods of analysis)
- 8) Sensitive and rapid liquid chromatography/tandem mass spectrometric assay for the quantification of chloroquine in dog plasma
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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