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CAS RN: 56238-63-2 | Product Number: C3747
Cefuroxime Sodium
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Purity: >97.0%(T)(HPLC)
Synonyms:
- Sodium (6R,7R)-3-[(Carbamoyloxy)methyl]-7-[2-(2-furyl)(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 1G |
€34.00
|
Ships within 2 weeks after ordering | 4 | |
| 5G |
€96.00
|
1 | 13 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | C3747 |
Purity / Analysis Method 
|
>97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__5N__4NaO__8S = 446.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 56238-63-2 |
| Reaxys Registry Number | 6560595 |
| PubChem Substance ID | 468591254 |
| MDL Number | MFCD09878727 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Volumetric Analysis) | min. 97.0 % |
| Specific rotation | +56.0 ～ +62.0 deg (C=1, Water) |
| Water | max. 3.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 186 °C(dec.) |
GHS
Related Laws:
| EC Number | 260-073-1 |
| RTECS# | XI0330000 |
Transport Information:
| HS Number | 2941900000 |
Application
Cefuroxime Sodium: A Second Generation Cephalosporin with Increased Stability to β-Lactamase
Cefuroxime (sodium) is a second generation semisynthetic cephalosporin known to interfere with the final stages of peptidoglycan synthesis in bacterial cell wall. Cefuroxime has a broad bactericidal activity against both Gram-positive and Gram-negative organisms. Cefuroxime has a methoxyimino group in the 7-position side chain. The methoxyimino group give cefuroxime stability against β-lactamase and enhances the antibacterial activity against Gram-negative organisms. For your reference, cefuroxime axetil [C3750] is an ester prodrug which permits the oral administration of cefuroxime. (The product is for research purpose only.)
References
- Cefuroxime, a new cephalosporin antibiotic: activity in vitro
- Cefuroxime, a new cephalosporin antibiotic: activity in vivo
- Cefuroxime: mechanisms of action, antimicrobial activity, pharmacokinetics, clinical applications, adverse reactions and therapeutic indications (a review)
- Cefuroxime: a review of its antibacterial activity, pharmacological properties and therapeutic use
- Analytical profile of cefuroxime sodium (a review of physical properties, synthesis, methods of analysis, stability-degradation, drug metabolism and pharmacokinetics of defuroxime sodium)
- Comparison of HPLC and UV spectrophotometric methods for the determination of cefuroxime sodium in pharmaceutical products
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