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Published TCIMAIL newest issue No.198
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CAS RN: 562-10-7 | Product Number: D5583
Doxylamine Succinate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N,N-Dimethyl-2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethanamine Succinate
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€74.00
|
Contact Us | 6 |
| 25G |
€242.00
|
Contact Us | 16 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D5583 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__2N__2O·C__4H__6O__4 = 388.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 562-10-7 |
| Related CAS RN | 469-21-6 |
| PubChem Substance ID | 468591428 |
| Merck Index (14) | 3441 |
| MDL Number | MFCD00056168 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of Ion-Pair) |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 109.0 to 113.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 111 °C |
| Solubility (soluble in) | Alcohol, Chloroform |
| Solubility (slightly sol. in) | Benzene, Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 209-228-7 |
| RTECS# | US9275000 |
Transport Information:
Application
Doxylamine Succinate: A First-Generation Anti-Histamine
Doxylamine succinate is a first-generation anti-histamine similar in structure to diphenhydramine [D4744]. Because of its sedative effect, it is often used for the treatment of insomnia and nausea in clinical use. (The product is for research purpose only.)
References
- Doxylamine succinate-pyridoxine hydrochloride (Diclegis) for the management of nausea and vomiting in pregnancy: an overview (a review)
- Simultaneous determination of pyridoxine hydrochloride and doxylamine succinate from tablets by ion pair reversed-phase high-performance liquid chromatography (RP-HPLC)
- Determination of the sleep aid ingredients diphenhydramine hydrochloride and doxylamine succinate in pharmaceutical products by quantitative HPTLC
- Simultaneous determination of dextromethorphan, dextrorphan and doxylamine in human plasma by HPLC coupled to electrospray ionization tandem mass spectrometry: Application to a pharmacokinetic study
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