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Published TCIMAIL newest issue No.201
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CAS RN: 93413-62-8 | Product Number: D5598
O-Desmethylvenlafaxine
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Purity: >98.0%(HPLC)
Synonyms:
- Desvenlafaxine
- 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 1G |
€54.00
|
3 | 23 | |
| 5G |
€267.00
|
1 | 15 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | D5598 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__5NO__2 = 263.38 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 93413-62-8 |
| Reaxys Registry Number | 4234613 |
| PubChem Substance ID | 468591443 |
| MDL Number | MFCD00871934 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 96.0 % |
| Melting point | 221.0 to 225.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 222 °C |
| Degree of solubility in water | 3,700 mg/l 25 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2922500090 |
Application
O-Desmethylvenlafaxine: An Active Metabolite of Venlafaxine Belonging to SNRIs
O-Desmethylvenlafaxine (desvenlafaxine, or ODV) is an active metabolite of venlafaxine [V0110] which belongs to a serotonin [S0370] /norepinephrine [A0906] reuptake inhibitors (SNRIs). It is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine [A0305] reuptake. It has no significant affinity for muscarinic cholinergic, H1-histaminergic, or α1-adrenergic receptors in vitro. (The product is for research purpose only.)
References
- Desvenlafaxine: a new antidepressant or just another one? (a review)
- Desvenlafaxine for major depressive disorder: incremental clinical benefits from a second-generation serotonin-norepinephrine reuptake inhibitor (a review)
- Rapid high-performance liquid chromatographic measurement of venlafaxine and O-desmethylvenlafaxine in human plasma. Application to management of acute intoxications
- High performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-MS/ESI) method for simultaneous determination of venlafaxine and its three metabolites in human plasma
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