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CAS RN: 130929-57-6 | Product Number: E0961
Entacapone
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide
- (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
€114.00
|
1 | ≥100 |
| 5G |
€342.00
|
2 | 20 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E0961 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__5N__3O__5 = 305.29 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 130929-57-6 |
| Reaxys Registry Number | 8158723 |
| PubChem Substance ID | 468591677 |
| Merck Index (14) | 3594 |
| MDL Number | MFCD00866580 |
Specifications
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 160.0 to 164.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 162 °C |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Methanol |
GHS
Related Laws:
| RTECS# | UC6316195 |
Transport Information:
| HS Number | 2926907090 |
Application
Entacapone: A Selective and Reversible Inhibitor of Catechol-O-methyltransferase (COMT)
Entacapone and tolcapone [T3856] are selective and reversible inhibitors of catechol-O-methyltransferase (COMT) which is one of several enzymes that degrade catecholamines (such as L-DOPA [D0600], dopamine [A0305], L-epinephrine [A0173], and norepinephrine [A0906]).1,2) COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including catecholamines. Entacapone and tolcapone cross the blood-brain barrier and can inhibit both peripheral and central COMT activity. Therefore, it has been suggested that entacapone and tolcapone prolong the biological half-life of L-DOPA and the therapeutic effect of L-DOPA for Parkinson's disease patients. Indeed, entacapone is currently in wide clinical use, while tolcapone can be used in restricted indications only, due to its hepatotoxicity.3) (The product is for research purpose only.)
References
- 1) Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone
- 2) Catechol-O-methyltransferase and its inhibitors in Parkinson's disease (a review)
- 3) Clinical advantages of COMT inhibition with entacapone - a review
- 4) High-performance liquid chromatography method for the quantification of entacapone in human plasma
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