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Maintenance Notice (5:30 - 10:30 PM June 28, 2025): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding

Published TCIMAIL newest issue No.198

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CAS RN: 69075-42-9 | Product Number: E1560

5-Ethynyluridine

Purity: >95.0%(T)(qNMR)

Synonyms:

5-EU
1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-ethynylpyrimidine-2,4(1H,3H)-dione

Product Documents:

Size	Unit Price	Belgium	Japan*
50MG	€45.00	Contact Us	3
250MG	€125.00	Contact Us	10

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).

General Information plus

Product Number	E1560
Purity / Analysis Method	>95.0%(T)(qNMR)
Molecular Formula / Molecular Weight	C__1__1H__1__2N__2O__6 = 268.23
Physical State (20 deg.C)	Solid
Storage Temperature	Refrigerated (0-10°C)
Store Under Inert Gas	Store under inert gas
Condition to Avoid	Air Sensitive,Heat Sensitive
CAS RN	69075-42-9
Reaxys Registry Number	686532
MDL Number	MFCD00876719

Specifications & Properties plus

Specifications

Appearance	White to Light yellow powder to crystal
Purity(Neutralization titration)	min. 95.0 %
Purity(qNMR)	min. 95.0 %
NMR	confirm to structure

Properties (reference)

Melting Point

190 °C

Safety & Regulations plus

GHS

Related Laws:

Transport Information:

HS Number

2934999090

Applications & Literature plus

Application

5-Ethynyluridine: A Clickable Form of Uridine

5-Ethynyluridine is a clickable form of uridine and can undergo azide-alkyne cycloaddition with molecules containing azide groups. It is incorporated into cellular RNA and has been used to detect transcription in vitro and in vivo.

References

Exploring RNA transcription and turnover in vivo by using click chemistry
- C. Y. Jao, A. Salic, Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 15779.
Capturing the interactome of newly transcribed RNA
- X. Bao, X. Guo, M. Yin, M. Tariq, Y. Lai, S. Kanwal, J. Zhou, N. Li, Y. Lv, C. Pulido-Quetglas, X. Wang, L. Ji, M. J. Khan, X. Zhu, Z. Luo, C. Shao, D.-H. Lim, X. Liu, N. Li, W. Wang, M. He, Y.-L. Liu, C. Ward, T. Wang, G. Zhang, D. Wang, J. Yang, Y. Chen, C. Zhang, R. Jauch, Y.-G. Yang, Y. Wang, B. Qin, M.-L. Anko, A. P. Hutchins, H. Sun, H. Wang, X.-D. Fu, B. Zhang, M. A. Esteban, Nat. Methods 2018, 15, 213.
Transcriptome-wide discovery of coding and noncoding RNA-binding proteins
- R. Huang, M. Han, L. Meng, X. Chen, Proc. Natl. Acad. Sci. U.S.A. 2018, 115, E3879.
In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration
- L. J. van’t Sant, J. J. White, J. H. J. Hoeijmakers, W. P. Vermeij, D. Jaarsma, Acta Neuropathol. Commun. 2021, 9, 94.

Product Documents (Note: Some products will not have analytical charts available.)

Safety Data Sheet (SDS)

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CAS RN: 69075-42-9 | Product Number: E1560