Published TCIMAIL newest issue No.198
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 30652-11-0 | Product Number: H0944
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
×
![]()
×
Purity: >98.0%(GC)(T)
Synonyms:
- Deferiprone
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€46.00
|
1 | ≥100 |
| 25G |
€165.00
|
1 | 36 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H0944 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__7H__9NO__2 = 139.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 30652-11-0 |
| Reaxys Registry Number | 1447108 |
| PubChem Substance ID | 87571300 |
| SDBS (AIST Spectral DB) | 16851 |
| Merck Index (14) | 2859 |
| MDL Number | MFCD00134497 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Acetic acid | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 260 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | UU7785940 |
Transport Information:
| HS Number | 2933399990 |
Application
Mitophagy research
References
- Loss of iron triggers PINK1/Parkin-independent mitophagy
- PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
Application
Deferiprone: A Potent Chelating Agent with an Affinity for Ferric Ion [Fe (III)]
Deferiprone is a potent chelating agent with an affinity for ferric ion [Fe (III)]. Reportedly, deferiprone binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. And then, deferiprone has a lower binding affinity for other metals such as copper, aluminum and zinc than for iron. Deferiprone, an iron chelator that may cross the blood-brain barrier, is used therapeutically in conditions of transfusional iron overload and Friedreich's ataxia (FRDA) for the excretion of iron. (The product is for research purpose only.)
References
- Role of deferiprone in chelation therapy for transfusional iron overload (a review)
- Oral chelators Deferasirox and Deferiprone for transfusional iron overload in thalassemia major: new data, new questions
- Deferiprone for the treatment of Friedreich's ataxia
- Chromatography of 3-hydroxypyridin-4-ones: novel orally active iron chelators
- Development of a fast LC-MS/MS assay for the determination of deferiprone in human plasma and application to pharmacokinetics
PubMed Literature
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.