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Published TCIMAIL newest issue No.198
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CAS RN: 149647-78-9 | Product Number: H1388
N-Hydroxy-N'-phenyloctanediamide
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Purity: >98.0%(HPLC)(N)
Synonyms:
- SAHA
- Suberoylanilidehydroxamic Acid
- Vorinostat
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 200MG |
€176.00
|
1 | ≥100 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H1388 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__4H__2__0N__2O__3 = 264.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 149647-78-9 |
| Reaxys Registry Number | 7213017 |
| PubChem Substance ID | 160871381 |
| Merck Index (14) | 10034 |
| MDL Number | MFCD00945317 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
Properties (reference)
| Melting Point | 155 °C |
| Degree of solubility in water | 1,167 mg/l 25 °C |
| Solubility (slightly sol. in) | Ethanol, Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | RG8835000 |
Transport Information:
| HS Number | 2924297099 |
Application
Hypoxia inducible factor (HIF) research / Hypoxia inducible factor (HIF) inhibitor
Reference
- Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth.
Application
Reticulophagy research / ER (endoplasmic reticulum) phagy
Reference
- Suberoylanilide hydroxamic acid upregulates reticulophagy receptor expression and promotes cell death in hepatocellular carcinoma cells
Application
Adeno-associated virus vector transduction enhancer
N-Hydroxy-N'-phenyloctanediamide (Vorinostat) increases transduction by adeno-associated virus (AAV) vectors.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
Application
HDAC Inhibitor
Suberoylanilidehydroxamic acid (SAHA) is a histone deacetylase (HDAC) inhibitor1,2) and inhibits both classes I and II enzymes by binding to the pocket of the catalytic site.3) The compound has been demonstrated to inhibit the proliferation of a wide variety of transformed cells in vitro.1)
References
- 1) Cancer biology: mechanism of antitumor action of vorinostat (suberoylanilide hydroxamic acid), a novel histone deacetylase inhibitor
- 2) A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
- 3) Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
PubMed Literature
Documents
Product Articles
[TCIMAIL No.157] HDAC Inhibitor[Research Articles] HDAC2 may be a New Target for Schizophrenia Treatment
Product Documents (Note: Some products will not have analytical charts available.)
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