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Published TCIMAIL newest issue No.199
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CAS RN: 957-77-7 | Product Number: H1865
5-Hydroxyuridine
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 1-β-D-Ribofuranosylisobarbituric Acid
- ho5U
- 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-hydroxypyrimidine-2,4(1H,3H)-dione
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 100MG |
€75.00
|
Contact Us | 38 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | H1865 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__9H__1__2N__2O__7 = 260.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 957-77-7 |
| Reaxys Registry Number | 33666 |
| MDL Number | MFCD00010571 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 245 °C |
| Maximum Absorption Wavelength | 280 nm (H__2O) |
GHS
Related Laws:
| EC Number | 213-487-1 |
Transport Information:
| HS Number | 2934999090 |
Application
5-Hydroxyuridine: One of the Oxidized Lesions of Uridine and Cytosine
5-Hydroxyuridine (ho5U) is one of the main lesions of uridine and cytosine produced in RNA by various oxidants.1,2) Oxidized pyrimidines, including 5-hydroxyuridine, are excised from RNA by single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1), a base-excision repair enzyme.3,4) In addition, A highly sensitive detection method for the detection of 5-hydroxyuridine in RNA has been reported.5)
References
- 1) Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in vitro
- 2) Synthesis and base pairing properties of DNA-RNA heteroduplex containing 5-hydroxyuridine
- S. Cui, Y.-H. Kim, C.-H. Jin, S. K. Kim, M.-h. Rhee, O.-S. Kwon, B. J. Moon, BMB Rep. 2009, 42, 373.
- 3) Pre-steady-state kinetic analysis of damage recognition by human single-strand selective monofunctional uracil-DNA glycosylase SMUG1
- 4) RNA Metabolism Guided by RNA Modifications: The Role of SMUG1 in rRNA Quality Control
- 5) Sensitive and Simultaneous Determination of Uridine Thiolation and Hydroxylation Modifications in Eukaryotic RNA by Derivatization Coupled with Mass Spectrometry Analysis
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