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Published TCIMAIL newest issue No.201
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CAS RN: 70288-86-7 | Product Number: I0819
Ivermectin
×
Purity: >93.0%(HPLC)
Synonyms:
- MK-933
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 1G |
62,00 €
|
3 | 21 | |
| 5G |
107,00 €
|
4 | Ships within 3-4 months after ordering |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | I0819 |
Purity / Analysis Method 
|
>93.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__8H__7__4O__1__4 = 875.11 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 70288-86-7 |
| Reaxys Registry Number | 8400552 |
| PubChem Substance ID | 468592054 |
| Merck Index (14) | 5248 |
| MDL Number | MFCD00869511 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 93.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 155 °C |
| Solubility (soluble in) | Diethyl ether, Methanol, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P273 : Avoid release to the environment. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P391 : Collect spillage. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 274-536-0 |
| RTECS# | IH7891500 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| HS Number | 2941900000 |
Application
Autophagy research / Mitophagy research
References
- Ivermectin induces mitophagy in H9c2 cells via activation of the PINK1/Parkin pathway
- Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction
- Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform
Application
Ivermectin: A Semisynthetic Anthelmintic Agent with Antiviral Activity
Ivermectin is a semisynthetic anthelmintic agent derived from the avermectins isolated from the fermentation products of Streptomyces avermitilis.1,2) Ivermectin contains B1a (C48H74O14) and B1b (C47H72O14), but the main component is B1a as shown in the figure. The mechanism of action of ivermectin is not fully understood, but it is strongly suggested to be related to glutamate-gated chloride channels in the muscles and nerves of nematode.2) Ivermectin binds with high affinity to glutamatergic chloride channels of nematode. As the result, the nematode is thought to be paralyzed. In addition, it has recently been reported that ivermectin has a broad spectrum of antiviral activity in vitro, including SARS-CoV-2.3,4) (The product is for research purpose only.)
References
- 1) Ivermectin 'Wonder drug' from Japan: the human use perspective (a review)
- 2) Ivermectin - Old Drug, New Tricks? (a review)
- 3) Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture
- 4) The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
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