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Published TCIMAIL newest issue No.201
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CAS RN: 143782-23-4 | Product Number: I0987
4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
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Purity: >98.0%(GC)
Synonyms:
- 4-Cyano-3-(trifluoromethyl)phenyl Isothiocyanate
- Isothiocyanic Acid 4-Cyano-3-(trifluoromethyl)phenyl Ester
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 1G |
€59.00
|
1 | 10 | |
| 5G |
€190.00
|
1 | 24 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | I0987 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__9H__3F__3N__2S = 228.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 143782-23-4 |
| Reaxys Registry Number | 9126063 |
| PubChem Substance ID | 354333057 |
| MDL Number | MFCD09800709 |
Specifications
| Appearance | White to Yellow to Green powder to lump |
| Purity(GC) | min. 98.0 % |
| Melting point | 39.0 to 43.0 °C |
Properties (reference)
| Melting Point | 41 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H335 : May cause respiratory irritation. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
Transport Information:
| HS Number | 2930909599 |
Application
A Synthetic Intermediate of Enzalutamide and Its Derivatives
This product is used for the synthesis of enzalutamide and its derivatives which are androgen-receptor antagonists used for the treatment of prostate cancer.
References
- Structure-Activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-Resistant Prostate Cancer (CRPC)
- Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer
- Design and synthesis of indoline thiohydantoin derivatives based on enzalutamide as antiproliferative agents against prostate cancer
- An improved and practical route for the synthesis of enzalutamide and potential impurities study
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Product Articles
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