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Published TCIMAIL newest issue No.198
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CAS RN: 165800-03-3 | Product Number: L0362
Linezolid
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Purity: >98.0%(HPLC)
Synonyms:
- (S)-N-[[3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl]methyl]acetamide
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 250MG |
37,00 €
|
Contact Us | ≥40 |
| 1G |
89,00 €
|
2 | 32 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0362 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__0FN__3O__4 = 337.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 165800-03-3 |
| Reaxys Registry Number | 7496939 |
| PubChem Substance ID | 468592166 |
| MDL Number | MFCD00937825 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 177.0 to 181.0 °C |
| Specific rotation | -7.0 to -9.0 deg(C=1, CHCl3) |
Properties (reference)
| Melting Point | 179 °C |
| Maximum Absorption Wavelength | 252 nm (H__2O) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 610 mg/l 25 °C |
| Solubility (slightly sol. in) | dichloromethane |
| Solubility (insoluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H372 : Causes damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P314 : Get medical advice/ attention if you feel unwell. |
Related Laws:
| RTECS# | AC2720000 |
Transport Information:
| HS Number | 2941900000 |
Application
Linezolid: A Synthetic Oxazolidinone Antibacterial with Excellent Activity against Gram-Positive Pathogens including Antibiotic-Resistant Bacteria
Linezolid (U-100766) is a synthetic oxazolidinone antibacterial which has excellent activity against virtually all important Gram-positive pathogens, including methicillin-resistant staphylococci (e.g. MRSA), penicillin-resistant pneumococci, macrolide-resistant streptococci, and vancomycin-resistant enterococci (VRE). In addition, the in vitro spectrum of activity of linezolid also includes certain Gram-negative bacteria and anaerobic bacteria. It has been reported that linezolid binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, which is an essential component of the bacterial translation process. In recent years, the emergence of bacteria resistant to linezolid has become a problem. (The product is for research purpose only.)
References
- In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents
- The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria
- Oxazolidinone structure-activity relationships leading to linezolid (a review)
- Linezolid: the first oxazolidinone antimicrobial (a review)
- The emerging problem of linezolid-resistant Staphylococcus (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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