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CAS RN: 3685-84-5 | Product Number: M2460
Meclofenoxate Hydrochloride
×
Purity: >98.0%(T)
Synonyms:
- 2-(Dimethylamino)ethyl 2-(4-Chlorophenoxy)acetate Hydrochloride
- 2-(4-Chlorophenoxy)acetic Acid 2-(Dimethylamino)ethyl Ester Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 1G |
€ 16,00
|
1 | 27 | |
| 5G |
€ 57,00
|
1 | 4 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | M2460 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__2H__1__6ClNO__3·HCl = 294.17 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 3685-84-5 |
| Related CAS RN
|
51-68-3 |
| Reaxys Registry Number | 3637332 |
| PubChem Substance ID | 253661831 |
| Merck Index (14) | 5780 |
| MDL Number | MFCD00012533 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 137.0 to 142.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 139 °C |
| Solubility (soluble in) | Acetone |
| Solubility (insoluble in) | Benzene, Ether, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 222-975-3 |
| RTECS# | AG0440000 |
Transport Information:
| HS Number | 2922190090 |
Application
Meclofenoxate Hydrochloride: A Compound Acting as a Precursor of Acetylcholine and a Free-Radical Scavenger
Meclofenoxate, also called centrophenoxine, is the ester made from 4-chlorophenoxyacetic acid [C0250] and 2-(dimethylamino)ethanol (also called dimethylaminoethanol or DMAE) [D0649]. It is reported that meclofenoxate increases the DMAE levels in the brain. DMAE is a precursor of acetylcholine, an important neurotransmitter in the brain. Therefore, meclofenoxate is widely recognized as a nootropic enhancer. In addition, DMAE is also reported as a free-radical scavenger and an antioxidant. (The product is for research purpose only.)
References
- Increases in choline levels in rat brain elicited by meclofenoxate
- On the role of intracellular physicochemistry in quantitative gene expression during aging and the effect of centrophenoxine. A review
- Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and citicholine (experiments on rats)
- Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine
- Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease
- Kinetic study on the degradation of meclophenoxate hydrochloride in alkaline aqueous solutions by high performance liquid chromatography
- A Simple and Sensitive HPLC Method for Quantification of the Metabolin of Meclofenoxate in Human Plasma
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