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CAS RN: 328086-60-8 | Product Number: M3533
Methyl N-(tert-Butoxycarbonyl)-3-[(3S)-2-oxo-3-pyrrolidinyl]-L-alaninate
![Thumbnail of Methyl N-(tert-Butoxycarbonyl)-3-[(3S)-2-oxo-3-pyrrolidinyl]-L-alaninate](/medias/Tci-98-M3533.jpg?context=bWFzdGVyfHJvb3R8MzA2NnxpbWFnZS9qcGVnfGFHRXdMMmcxTkM4NU16azRNekUyTkRBd05qY3dMMVJqYVMwNU9GOU5NelV6TXk1cWNHY3w0YzYwOWY3OGQ4ZDBkZTQzMDdkMGE5ZjJkOTY1ZWUyODBmZmEwMzFiZDYzNGMzNjU2NWI2MWYyYjhhM2VkYTZl "Methyl N-(tert-Butoxycarbonyl)-3-[(3S)-2-oxo-3-pyrrolidinyl]-L-alaninate")
![Chemical Structure of Methyl N-(tert-Butoxycarbonyl)-3-[(3S)-2-oxo-3-pyrrolidinyl]-L-alaninate](/medias/Tci-440-M3533.jpg?context=bWFzdGVyfHJvb3R8MTk4NjR8aW1hZ2UvanBlZ3xhR1UyTDJnMU1TODVNems0TXpFMk16WTNPVEF5TDFSamFTMDBOREJmVFRNMU16TXVhbkJufGU1ODQ3MmI1OTM0ODg0ZDBhZDVjNzk5YmY3MTIwOWY0OTQzZDVhNWNiMjExNTJlZGVhZGYyMWUyMTRiMGQ1NTI "Methyl N-(tert-Butoxycarbonyl)-3-[(3S)-2-oxo-3-pyrrolidinyl]-L-alaninate")
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![Methyl N-(tert-Butoxycarbonyl)-3-[(3S)-2-oxo-3-pyrrolidinyl]-L-alaninate](/_ui/responsive/theme-tci/images/missing_product_zoom.webp "Methyl N-(tert-Butoxycarbonyl)-3-[(3S)-2-oxo-3-pyrrolidinyl]-L-alaninate")
Purity: >98.0%(T)(HPLC)
Synonyms:
- Methyl (S)-2-[(tert-Butoxycarbonyl)amino]-3-[(S)-2-oxopyrrolidin-3-yl]propanoate
- Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate
- (αS,3S)-α-[(tert-Butyloxycarbonyl)amino]-2-oxo-3-pyrrolidinepropanoic Acid Methyl Ester
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 5G |
€77.00
|
1 | 25 | |
| 25G |
€271.00
|
Contact Us | 7 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | M3533 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__2__2N__2O__5 = 286.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 328086-60-8 |
| Reaxys Registry Number | 8991735 |
| MDL Number | MFCD28138267 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 111.0 to 115.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 114 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933790090 |
Application
A Key Synthetic Intermediate for Antiviral Protease Inhibitors
This product has been used as a key synthetic intermediate for antiviral protease inhibitors including GC376 and nirmatrelvir.
References
- Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
- Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine
- Optimized Synthesis of a Key Intermediate of Nirmatrelvir
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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