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Published TCIMAIL newest issue No.201
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CAS RN: 14417-88-0 | Product Number: M3871
Melinamide
×
Purity: >95.0%(GC)
Synonyms:
- (9Z,12Z)-N-(1-Phenylethyl)-9,12-octadecadienamide
- AC 223
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 50MG |
250,00 €
|
Contact Us | 1 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
Due to the limited filling volume, some of the product may stick to the inner walls of the bottle.
| Product Number | M3871 |
Purity / Analysis Method 
|
>95.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__6H__4__1NO = 383.62 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 14417-88-0 |
| Reaxys Registry Number | 2950179 |
| MDL Number | MFCD01716255 |
Specifications
| Appearance | Colorless to Light yellow clear liquid |
| Purity(GC) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Boiling Point | 217 °C/0.05 mmHg |
GHS
Related Laws:
| RTECS# | OI9410000 |
Transport Information:
| HS Number | 2924297099 |
Application
Melinamide: A Potent and Selective Inhibitor of ACAT
Melinamide is a potent and selective inhibitor of Acyl-Coenzyme A (ACAT, also known as sterol O-acyltransferase or SOAT), which is an intracellular enzyme that catalyzes the formation of cholesteryl esters from cholesterol and fatty acyl-CoA.1,2) Recently, many studies have suggested that ACAT-1 (SOAT-1) plays a critical role in cancer initiation and progression and is an attractive target for novel anticancer therapies.2,3) (The product is for research use only.)
References
- 1) Formation of fatty acid ethyl esters in rat liver microsomes
- 2) Targeting Sterol O-Acyltransferase/Acyl-CoA: Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential (a review)
- 3) Cholesterol metabolism: New functions and therapeutic approaches in cancer (a review)
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