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CAS RN: 63612-50-0 | Product Number: N1212
Nilutamide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5,5-Dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione
- 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
€93.00
|
Contact Us | 1 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N1212 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__0F__3N__3O__4 = 317.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 63612-50-0 |
| Reaxys Registry Number | 841906 |
| PubChem Substance ID | 468592515 |
| MDL Number | MFCD00864670 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 153.0 to 157.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 155 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| RTECS# | NI9453300 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933299090 |
Application
Nilutamide: A Nonsteroidal Anti-Androgen
Nilutamide is a nonsteroidal anti-androgen with affinity for androgen receptors but not for progestogen, estrogen, or glucocorticoid receptors. In vivo, nilutamide preferentially binds to androgen receptors and blocks androgen receptor activation by testosterone and other androgens. Therefore, nilutamide is used in the treatment of prostate cancer, which is known to be androgen sensitive. (The product is for research purpose only.)
References
- Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer
- Receptor affinity and potency of non-steroidal antiandrogens: translation of preclinical findings into clinical activity (a review)
- Square wave adsorptive stripping voltammetric determination of anticancer drug nilutamide nilutamide in biological fluids using cationic surfactant cetyltrimethylammonium bromide
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