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Published TCIMAIL newest issue No.201
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CAS RN: 18637-83-7 | Product Number: O0200
1,1'-Oxalyldiimidazole
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Purity: >95.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 1G |
19,00 €
|
3 | 16 | |
| 5G |
62,00 €
|
3 | 11 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | O0200 |
Purity / Analysis Method 
|
>95.0%(T) |
| Molecular Formula / Molecular Weight | C__8H__6N__4O__2 = 190.16 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Moisture Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 18637-83-7 |
| Reaxys Registry Number | 611833 |
| PubChem Substance ID | 87574196 |
| MDL Number | MFCD00043067 |
Specifications
| Appearance | Light yellow to Brown to Dark green powder to crystal |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933299090 |
Application
Condensing Agent
Experimental procedure2): A stirred solution of N-protected α-amino acid (10 mmol) in acetonitrile (30 mL) is cooled to 10 °C and treated with 1,1'-oxalyldiimidazole (2.09 g, 11 mmol) while maintaining the reaction temperature at below 15 °C. Stirring is continued for 1 h at 15-20 °C, then a mixture of α-amino acid ester hydrochloride (10 mmol) and triethylamine (10 mmol) in acetonitrile (5 mL) is added. The resultant mixture is stirred for 2 h at 10-15 °C. After removal of the solvent in vacuo, the residue is dissolved in ethyl acetate and the organic solution is washed with 5% NaHCO3, 2% HCl, and brine, then dried over anhydrous Na2SO4. The organic solvent is evaporated off in vacuo to give the crude dipeptide, which is purified by recrystallization.
References
- 1)1,1’-OXALYLDIIMIDAZOLE, A NEW REAGENT FOR ACTIVATION OF CARBOXYLIC ACID
- 2)Facile Conversions of Carboxylic Acids into Amides, Esters, and Thioesters Using 1,1'-Oxalyldiimidazole and 1,1'-Oxalyldi (1,2,4-triazole)
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