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CAS RN: 763113-22-0 | Product Number: O0689
Olaparib
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Purity: >95.0%(HPLC)
Synonyms:
- AZD-2281
- 4-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorobenzyl]phthalazin-1(2H)-one
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 1G |
€79.00
|
Contact Us | Contact Us |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | O0689 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__2__3FN__4O__3 = 434.47 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 763113-22-0 |
| Reaxys Registry Number | 12051534 |
| MDL Number | MFCD13185161 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 209.0 to 213.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 211 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H360 : May damage fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. H336 : May cause drowsiness or dizziness. |
| Precautionary Statements | P260 : Do not breathe dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| RTECS# | TH9203962 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933599590 |
Application
Olaparib: An Inhibitor of Poly(ADP-ribose) Polymerase (PARP) Enzymes
Poly(ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3, play a role in normal cellular functions such as DNA transcription and repair of single-strand DNA breaks. Inhibition of PARPs alone is not lethal because DNA lesions can be repaired by other DNA repair pathways, specifically homologous recombination repair (HRR). Conversely, BRCA1 and BRCA2 proteins are crucial for the accurate repair of double-strand DNA breaks through the HRR pathway. Consequently, cancer cells deficient in BRCA1 and BRCA2 are hypersensitive to PARP inhibitors. Olaparib inhibits PARPs and has been shown to inhibit the growth of select cancer cell lines in vivo and in vitro. In vitro studies have demonstrated that olaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increases the formation of PARP-DNA complexes, resulting in DNA damage and cancer cell death. (The product is for research use only.)
References
- Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
- Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
- Targeting the DNA Damage Response in Cancer (a review)
- A decade of clinical development of PARP inhibitors in perspective (a review)
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