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Published TCIMAIL newest issue No.198
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CAS RN: 99-66-1 | Product Number: P0823
2-Propylvaleric Acid
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Purity: >99.0%(GC)(T)
Synonyms:
- Dipropylacetic Acid
- Valproic Acid
- 2-Propylpentanoic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 25ML |
€45.00
|
2 | ≥40 |
| 100ML |
€123.00
|
1 | ≥100 |
| 500ML |
€394.00
|
4 | ≥40 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P0823 |
| Purity / Analysis Method | >99.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__8H__1__6O__2 = 144.21 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 99-66-1 |
| Reaxys Registry Number | 1750447 |
| PubChem Substance ID | 87574953 |
| SDBS (AIST Spectral DB) | 6250 |
| Merck Index (14) | 9913 |
| MDL Number | MFCD00002672 |
Specifications
| Appearance | Colorless to Light yellow to Light orange clear liquid |
| Purity(GC) | min. 99.0 % |
| Purity(Neutralization titration) | min. 99.0 % |
Properties (reference)
| Boiling Point | 220 °C |
| Flash point | 126 °C |
| Specific Gravity (20/20) | 0.91 |
| Refractive Index | 1.43 |
| Degree of solubility in water | 2 g/l 20 °C |
| Solubility (soluble in) | Chloroform, Ether, Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 202-777-3 |
| RTECS# | YV7875000 |
Transport Information:
| HS Number | 2915907098 |
Application
Valproic Acid: A GABA Enhancer and a HDAC Inhibitor
Valproic acid and its sodium salt [S0894] are one of the major antiepileptic agents. The mechanisms of action have not been established. However, it has been suggested that its activity in epilepsy is related to increased brain concentrations of γ-aminobutyric acid (GABA) [A0282] and dopamine [A0305] in brain.1,2) Furthermore, valproic acid and its sodium salt have recently been shown to inhibit histone deacetylases (HDACs) which play important roles in regulation of gene transcription and pathogenesis of cancer.3-5) (The product is for research purpose only.)
References
- 1)Effects of Sodium Dipropylacetate on γ-Aminobutyric Acid and Biogenic Amines in Rat Brain
- 2)Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action (a review)
- 3)Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
- 4)Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
- 5)Histone Deacetylase Inhibitors: Overview and Perspectives
- 6)Simple and sensitive fluorimetric liquid chromatography method for the determination of valproic acid in plasma
- 7)A high throughput and selective method for the estimation of valproic acid an antiepileptic drug in human plasma by tandem LC-MS/MS
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