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CAS RN: 318-98-9 | Product Number: P0995
Propranolol Hydrochloride
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Purity: >99.0%(T)(HPLC)
Synonyms:
- 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 25G |
€98.00
|
8 | ≥100 | |
| 250G |
€611.00
|
1 | 1 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | P0995 |
Purity / Analysis Method 
|
>99.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__1NO__2·HCl = 295.81 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 318-98-9 |
| Related CAS RN
|
525-66-6 |
| Reaxys Registry Number | 4164259 |
| PubChem Substance ID | 87575108 |
| Merck Index (14) | 7840 |
| MDL Number | MFCD00012558 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Melting point | 163.0 to 168.0 °C |
| Solubility in hot Water | almost transparency |
Properties (reference)
| Melting Point | 166 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Alcohol |
| Solubility (insoluble in) | Ether, Benzene |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 206-268-7 |
| RTECS# | UB7525000 |
Transport Information:
| HS Number | 2922500090 |
Application
Propranolol Hydrochloride: A Non-Selective and Catecholamine Competitive β-Adrenergic Receptor Antagonist
Propranolol hydrochloride is a non-selective and competitive catecholamine β-adrenergic receptor antagonist. Propranolol blocks β1 (myocardial)- and β2(pulmonary, vascular and uterine)-adrenergic receptor site. There are two enantiomers of propranolol, and it is reported that the S-enantiomer blocks β-adrenergic receptors. The mechanism of the antihypertensive effects of propranolol has not been clearly established. However, propranolol may reduce the oxygen requirement of the heart at any level of effort by blocking catecholamine (such as dopamine [A0305], noradrenaline [A0906] and adrenaline [A0173])-induced increases in the heart rate, systolic blood pressure and the velocity and extent of myocardial contraction. (The product is for research purpose only.)
References
- Some effects of propranolol on the central nervous system
- Propranolol metabolism in man and dog: mass spectrometric identification of six new metabolites
- Plasma Propranolol Levels in the Quantitative Assessment of β-adrenergic Blockade in Man
- Stereoselective vascular effects of the (R)- and (S)-enantiomers of propranolol and atenolol
- Enantioselective bioanalysis of beta-blocking agents: focus on atenolol, betaxolol, carvedilol, metoprolol, pindolol, propranolol and sotalol
Application
Reagent for cardiomyopathy model
References
- The beneficial effect of amrinone on acute drug-induced heart failure in the anaesthetised dog
- Levosimendan as a rescue drug in experimental propranolol-induced myocardial depression: a randomized study
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