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CAS RN: 135729-62-3 | Product Number: P2051
Palonosetron Hydrochloride
×
Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 200MG |
€60.00
|
1 | 17 | |
| 1G |
€212.00
|
1 | 11 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | P2051 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__4N__2O·HCl = 332.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 135729-62-3 |
| Related CAS RN
|
135729-61-2 |
| Reaxys Registry Number | 21177207 |
| PubChem Substance ID | 253660260 |
| Merck Index (14) | 6997 |
| MDL Number | MFCD07370072 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -88.0 to -93.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 307 °C(dec.) |
| Specific Rotation | -89° (C=1,CHCl3) |
GHS
Related Laws:
Transport Information:
| HS Number | 2933790090 |
Application
Palonosetron Hydrochloride: a Selective 5-HT3 Receptor Antagonist (5-HT3-RA)
Palonosetron hydrochloride is a selective 5-HT3 receptor antagonist (5-HT3-RA) with a longer human plasma half-life (-40 h) and a higher binding affinity than older first-generation 5-HT3-RAs.
References
- 2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists
- Palonosetron: a unique 5-HT3-receptor antagonist for the prevention of chemotherapy-induced emesis
- Palonosetron: a second-generation 5-hydroxytryptamine receptor antagonist
- Palonosetron Exhibits Unique Molecular Interactions with the 5-HT3 Receptor
- Palonosetron triggers 5-HT3 receptor internalization and causes prolonged inhibition of receptor function
- Pharmacological mechanisms of 5-HT3 and tachykinin NK1 receptor antagonism to prevent chemotherapy-induced nausea and vomiting
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