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CAS RN: 82586-55-8 | Product Number: Q0082
Quinapril Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (S)-2-[[(S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 250MG |
€125.00
|
Contact Us | 19 |
| 1G |
€265.00
|
Contact Us | 30 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | Q0082 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__3__0N__2O__5·HCl = 474.98 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 82586-55-8 |
| Reaxys Registry Number | 5699760 |
| MDL Number | MFCD00889215 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation | +14.0 to +16.0 deg(C=2, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 130 °C |
| Solubility (insoluble in) | Diethyl ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | NW7176000 |
Transport Information:
| HS Number | 2933499090 |
Application
Quinapril Hydrochloride: A Non-Peptide, Non-Sulfhydryl Angiotensin- Converting Enzyme (ACE) Inhibitor
Angiotensin-converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor, angiotensin II. Quinapril hydrochloride is an orally active, non-peptide, non-sulfhydryl angiotensin- converting enzyme (ACE) inhibitor. It is a prodrug and is de-esterified to the principal metabolite, quinaprilat, which is an inhibitor of ACE activity in human subjects and animals. The effects of quinapril in hypertension and in congestive heart failure (CHF) appear to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation. (The product is for research use only.)
References
- Quinapril—A Preclinical Review of the Pharmacology, Pharmacokinetics, and Toxicology
- Quinapril. A review of its pharmacological properties, and therapeutic efficacy in cardiovascular disorders
- Quinapril: A further update of its pharmacology and therapeutic use in cardiovascular disorders
- Improving the detection of degradants and impurities in pharmaceutical drug products by applying mass spectral and chromatographic searching
- Determination of losartan potassium, quinapril hydrochloride and hydrochlorothiazide in pharmaceutical preparations using derivative spectrophotometry and chromatographic-densitometric method
Product Documents (Note: Some products will not have analytical charts available.)
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