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Published TCIMAIL newest issue No.201
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CAS RN: 93793-83-0 | Product Number: R0178
Roxatidine Acetate Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Acetoxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 200MG |
€23.00
|
1 | 13 | |
| 1G |
€81.00
|
1 | 7 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | R0178 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__8N__2O__4·HCl = 384.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 93793-83-0 |
| Reaxys Registry Number | 5915111 |
| PubChem Substance ID | 253661076 |
| Merck Index (14) | 8274 |
| MDL Number | MFCD00941429 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 146.0 to 150.0 °C |
Properties (reference)
| Melting Point | 148 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | AC3855000 |
Transport Information:
| HS Number | 2933399999 |
Application
Roxatidine Acetate Hydrochloride: A Specific and Competitive H2-Receptor Antagonist
Roxatidine acetate hydrochloride is a specific and competitive H2-receptor antagonist. Roxatidine acetate and its main metabolite roxatidine inhibit histamine-induced gastric acid secretion with a potency greater than that of cimetidine [C1252] and ranitidine [R0073]. In addition, H2-receptor antagonists such as roxatidine acetate and cimetidine are known to suppress the growth of several tumors including gastrointestinal cancer by reducing vascular endothelial growth factor (VEGF) expression.
References
- A review of the animal pharmacology of roxatidine acetate
- Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic
- Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages
- Determination of roxatidine in human plasma by liquid chromatography/electrospray mass spectrometry and application to a clinical pharmacokinetic study
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