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Published TCIMAIL newest issue No.198
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CAS RN: 13553-79-2 | Product Number: R0200
Rifamycin S
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Purity: >98.0%(HPLC)
Synonyms:
- 1,4-Dideoxy-1,4-dihydro-1,4-dioxorifamycin
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
€128.00
|
2 | 15 |
| 5G |
€410.00
|
1 | 25 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | R0200 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__7H__4__5NO__1__2 = 695.76 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 13553-79-2 |
| Reaxys Registry Number | 604802 |
| PubChem Substance ID | 354335535 |
| Merck Index (14) | 8217 |
| MDL Number | MFCD06198807 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 96.0 % |
| Specific rotation [a]20/D | +451 to +500 deg(C=0.1, methanol) |
Properties (reference)
| Melting Point | 201 °C |
| Specific Rotation | 476° (C=0.1,MeOH) |
| Maximum Absorption Wavelength | 390 nm (MeOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H371 : May cause damage to organs. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P405 : Store locked up. |
Related Laws:
| EC Number | 236-938-4 |
| RTECS# | KD1925000 |
Transport Information:
| HS Number | 2941900000 |
Application
Rifamycin S: A "Classic" Rifamycin with Potent Antimicrobial Activity but Poor Tolerability
Rifamycin S belongs to the family of ansamycin antibiotics, rifamycins. Initially, rifamycins were discovered referred to as rifamycin A, B, C, D, E in 1957. Among these, rifamycin B isolated in a pure form. Although its antimicrobial activity was moderate, it was oxidized and hydrolyzed to yield the highly active rifamycin S, a quinone molecular with potent antimicrobial activity but poor tolerability. Rifamycins inhibit DNA-dependent RNA polymerase in susceptible strains of bacteria, including Mycobacterium tuberculosis and Gram-positive bacteria. The rifamycin group includes the "classic" rifamycins as well as active rifamycin derivatives, rifampicin [R0079], rifaximin [R0101] and rifabutin [R0211]. (The product is for research purpose only.)
References
- Correlation of structure and activity in ansamycins: structure, conformation, and interactions of antibiotic rifamycin S
- A comparative study of the redox-cycling of a quinone (rifamycin S) and a quinonimine (rifabutin) antibiotic by rat liver microsomes
- Rifamycin-Mode of Action, Resistance, and Biosynthesis (a review)
- Identification and quantitation of rifamycins by reversed-phase high-performance liquid chromatography
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