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CAS RN: 99755-59-6 | Product Number: R0220
Rotigotine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (S)-6-[Propyl[2-(thiophen-2-yl)ethyl]amino]-5,6,7,8-tetrahydronaphthalen-1-ol
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 10MG |
€96.00
|
1 | Contact Us |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | R0220 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__5NOS = 315.48 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 99755-59-6 |
| Reaxys Registry Number | 5822772 |
| PubChem Substance ID | 468592791 |
| MDL Number | MFCD00869590 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -34.0 ～ -38.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 78 °C |
| Specific Rotation | -42.7° (C=1,MeOH) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 37.4 mg/l 25 °C |
| Solubility (soluble in) | Dimethylformamide, Ethanol |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
| RTECS# | QK4252968 |
Transport Information:
| HS Number | 2934999090 |
Application
Rotigotinei: A Non-Ergot Dopamine Receptor Agonist
Rotigotinei is a non-ergot dopamine receptor agonist. Rotigotinei is used as a curative medicine via a transdermal system for Parkinson's disease and restless legs syndrome. The precise mechanism of action of rotigotinei is unknown, although it is thought to be related to its ability to stimulate dopamine receptors. (The product is for research purpose only.)
References
- The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease
- Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors
- Rotigotine transdermal patch: a review of its use in the treatment of Parkinson's disease
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