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Published TCIMAIL newest issue No.201
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CAS RN: 199864-86-3 | Product Number: R0221
RS-127445 Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- 4-(4-Fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 10MG |
€103.00
|
Contact Us | 3 | |
| 50MG |
€353.00
|
Contact Us | 13 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | R0221 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__6FN__3·HCl = 317.79 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 199864-86-3 |
| Reaxys Registry Number | 11735151 |
| PubChem Substance ID | 468592792 |
| MDL Number | MFCD11112196 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 12.60 to 13.80 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 158 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933599590 |
Application
RS-127445 Hydrochloride: A Selective and Orally Bioavailable 5-HT2B Receptor Antagonist
RS-127445 hydrochloride is a selective and orally bioavailable 5-HT2B receptor antagonist which was at first developed for the prophylactic treatment of migraine. Recently, it has been reported that RS-127445 modulate visceral hypersensitivity. (The product is for research purpose only.)
References
- RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist
- Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology
- 5-HT2B receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction
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