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Published TCIMAIL newest issue No.198
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CAS RN: 83-67-0 | Product Number: T0178
Theobromine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3,7-Dimethylxanthine
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 25G |
€36.00
|
11 | ≥80 |
| 100G |
€96.00
|
2 | 11 |
| 500G |
€309.00
|
1 | 16 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T0178 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__7H__8N__4O__2 = 180.17 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 83-67-0 |
| Reaxys Registry Number | 16464 |
| PubChem Substance ID | 87576171 |
| SDBS (AIST Spectral DB) | 3455 |
| Merck Index (14) | 9282 |
| MDL Number | MFCD00022830 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 350 °C |
| Solubility (soluble in) | Solution of sodium hydroxide in water |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 201-494-2 |
| RTECS# | XH2275000 |
Transport Information:
| HS Number | 2939799090 |
Application
Efflux pump research
Theobromine has been reported to inhibit efflux pump in Gram-negative bacteria thereby having the synergy with ciprofloxacin [C2510] on antibacterial activity.1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- 1) Natural and synthetic compounds such as trimethoprim behave as inhibitors of efflux in Gram-negative bacteria
- 1) Determination of theobromine, theophylline and caffeine in cocoa samples by a high-performance liquid chromatographic method with on-line sample cleanup in a switching-column system
- 2) Theobromine and the pharmacology of cocoa (a review)
- 3) Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice
- 4) Recent advances in caffeine and theobromine toxicities: a review
Application
Theobromine: A Bioactive Purine Alkaloid Contained in Coffee and Cocoa Based Foods
Theobromine, a purine alkaloid, is one of the abundant methylxanthine in coffee and cocoa based foods.1) Biological studies have been suggested that theobromine works as an adenosine receptor antagonist,2) and a phosphodiesterase (PDE) inhibitor to increase intracellular cyclic adenosine monophosphate (cAMP) [A2381].3) In addition, theobromine is a caffeine [C2042] metabolite which plays an important role in the biochemical processes of mammalian organisms.4) (The product is for research purpose only.)
References
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Documents
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