Published TCIMAIL newest issue No.201
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 58880-19-6 | Product Number: T2477
Trichostatin A
×
Purity: >98.0%(HPLC)
Synonyms:
- TSA
- [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 10MG |
€ 318,00
|
Ships within 3 weeks after ordering | ≥60 | |
| 50MG |
€ 1.192,00
|
2 | 12 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T2477 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__2N__2O__3 = 302.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 58880-19-6 |
| Reaxys Registry Number | 2391788 |
| PubChem Substance ID | 87560260 |
| Merck Index (14) | 9649 |
| MDL Number | MFCD03848392 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Optical purity(LC) | min. 95.0 ee% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 144 °C(dec.) |
| Specific Rotation | 136° (C=0.3,MeOH) |
| Solubility (slightly sol. in) | Alcohol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | MI5215000 |
Transport Information:
| HS Number | 2928009090 |
Application
Trichostatin A: A Potent Inhibitor of Histone Deacetylases (HDACs) with Potent Antitumor Activity
Trichostatin A(R-enantiomer) was originally developed as an antifungal antibiotic agent isolated from the metabolites of strains of Streptomyces hygroscopicus in 1976.1) From the 1980s onwards, it has been reported that trichostatin A is a potent inhibitor of histone deacetylases (HDACs) with potent antitumor activity.2-7) Trichostatin A causes the induction of cell differentiation and specific inhibition of the cell cycle in the G1 and G2 phases at the very low concentrations.For your reference, trichostatin A (R-enantiomer) is the more active enantiomer (eutomer) of (-)-trichostatin A (S-enantiomer) [T3633] (The product is for research purpose only.)
References
- 1)A new antifungal antibiotic, trichostatin
- 2)Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
- 3)Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
- 4)Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function (a review)
- 5)The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells (a review)
- 6)Trichostatin A - like hydroxamate histone deacetylase inhibitors as therapeutic agents: Toxicological point of view (a review)
- 7)Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A
Application
iPS cell generation boosting compounds
Reference
- Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
PubMed Literature
Documents
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
Enter TCI Product Number
Enter KISHIDA Product Number
4-5 alphanumeric characters before the hyphen
7 alphanumeric characters
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
• The requested SDS is not available.
Specifications
The requested specifications are not available.
Please Contact Us for more information.
The requested specifications are not available.
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
• Please check that the lot number you have entered is correct. It is 4-5 alphanumeric characters before the hyphen. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
• If your information is correct and you are still not able to view the requested certificates, Please Contact Us for more information.
• Please check that the lot number you have entered is correct. It is 7 alphanumeric characters. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
The requested analytical chart is not available. Sorry for the inconvenience.