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Published TCIMAIL newest issue No.198
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CAS RN: 64-75-5 | Product Number: T2525
Tetracycline Hydrochloride
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Purity: >98.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 25G |
€41.00
|
33 | ≥40 |
| 100G |
€112.00
|
8 | ≥40 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2525 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__2__2H__2__4N__2O__8·HCl = 480.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 64-75-5 |
| Related CAS RN | 60-54-8 |
| Reaxys Registry Number | 3844873 |
| PubChem Substance ID | 87560362 |
| Merck Index (14) | 9196 |
| MDL Number | MFCD00078142 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -240 to -255 deg(C=0.5, 0.1mol/L HCl) |
Properties (reference)
| Melting Point | 214 °C(dec.) |
| Specific Rotation | -253° (C=0.5,0.1mol/L HCl) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| EC Number | 200-593-8 |
| RTECS# | QI9100000 |
Transport Information:
| HS Number | 2941300000 |
Application
DNA aptamer research
Reference
- Single-stranded DNA aptamers specific for antibiotics tetracyclines
Application
Tetracycline: a Broad Spectrum Polyketide Antibiotic and a Selective Reagent Genetically Engineered Cells
Tetracycline is a polyketide antibiotic isolated from Streptomyces genus. Tetracycline has broad activity against Gram-negative bacteria and Gram-positive bacteria, with a few exceptions, such as Pseudomonas aeruginosa and Proteus species. Tetracycline inhibits protein synthesis in susceptible organisms by binding to the A-site on the 50S subunit of a bacterial ribosome. However, tetracycline-resistant bacterial strains appeared soon after its introduction. Tetracycline is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for tetracycline resistance, which is one of the most frequently used selection markers for obtaining transgenic cells. Recently, tetracycline is used for tetracycline-controlled transcriptional activation systems in cells.
References
- Tetracyclines. Antibiotic action, uptake, and resistance mechanisms (a review)
- Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3
- The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit
- Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution (a review)
- Update on acquired tetracycline resistance genes
- In vivo gene regulation using tetracycline-regulatable systems
PubMed Literature
Documents
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