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Published TCIMAIL newest issue No.201
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CAS RN: 602-41-5 | Product Number: T2919
Thiocolchicoside
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 20MG |
€52.00
|
1 | 4 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T2919 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__3__3NO__1__0S = 563.62 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 602-41-5 |
| Reaxys Registry Number | 72205 |
| PubChem Substance ID | 253659834 |
| Merck Index (14) | 9324 |
| MDL Number | MFCD07995056 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 220 °C(dec.) |
GHS
Related Laws:
| EC Number | 210-017-7 |
| RTECS# | AC2976015 |
Transport Information:
| HS Number | 2930909599 |
Application
Thiocolchicoside: A Selective γ-Aminobutyric Acid Subtype A (GABAA) Receptor Antagonist
Thiocolchicoside is a synthetic derivative of colchicine which is an alkaloid extracted from Colchicum and Glory Lity. It has been suggested that thiocolchicoside acts as a selective γ-aminobutyric acid subtype A (GABAA) receptor antagonist in the central nervous system (CNS), and etc. The precise mechanism of action is unknown, but thiocolchicoside is used as a muscle relaxant with anti-inflammatory and analgesic effects. (The product is for research purpose only.)
References
- Affinity of thiocolchicoside and thiocolchicoside analogs for the postsynaptic GABA receptor site
- The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system
- Thiocolchicoside as muscle relaxant: a review
- Thiocolchicoside a semi-synthetic derivative of the Glory Lily: a new weapon to fight metastatic bone resorption?
- Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug
- Simultaneous estimation of thiocolchicoside and aceclofenac in pharmaceutical dosage form by spectrophotometric and LC method
- Simultaneous UV-spectrophotometric determination of thiocolchicoside and diclofenac in pharmaceutical formulation
PubMed Literature
Product Articles
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