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CAS RN: 181934-29-2 | Product Number: T3272
1-[(Trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one
Purity: >98.0%(T)
Synonyms:
- TMS-EBX
Product Documents:
Size | Unit Price | Belgium | Japan* |
---|---|---|---|
1G |
€127.00
|
1 | 22 |
5G |
€473.00
|
1 | 5 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Product Number | T3272 |
Purity / Analysis Method | >98.0%(T) |
Molecular Formula / Molecular Weight | C__1__2H__1__3IO__2Si = 344.22 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Refrigerated (0-10°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
CAS RN | 181934-29-2 |
Reaxys Registry Number | 7707098 |
PubChem Substance ID | 354333836 |
Specifications
Appearance | White to Light yellow to Light orange powder to crystal |
Purity(Precipitation Titration) | min. 98.0 % |
Properties (reference)
Melting Point | 140 °C(dec.) |
GHS
Pictogram | |
Signal Word | Warning |
Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
HS Number | 2934999090 |
Application
An Ethynylating Agent
Experimental procedure1): A solution of 1 (89 mg, 0.40 mmol, 1.0 eq.) and TMS-EBX (179 mg, 0.520 mmol, 1.3 eq.) in dried THF (6 mL) is stirred at -78 °C for 5 min under nitrogen. After this period of time, TBAF (1 mol/L in THF, 1.3 eq.) is added and mixture is vigorously stirred for 1 h at -78 °C. The reaction mixture is quenched with deactivated silica gel and the solvent is evaporated under reduced pressure. The product is purified by flash chromatography (SiO2, Hexane:EtOAc = 8:1) to afford 2 (92 mg, 0.37 mmol, 93%) as yellow oil.
References
- 1)Ethynyl-1,2-benziodoxol-3(1H)-one (EBX): An Exceptional Reagent for the Ethynylation of Keto, Cyano, and Nitro Esters
- 2)A Highly Chemoselective and Practical Alkynylation of Thiols
PubMed Literature
Articles/Brochures
TCIMAIL
[Product Highlights] Useful Hypervalent Iodine Compound for the Introduction of an Ethynyl GroupProduct Documents (Note: Some products will not have analytical charts available.)
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