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CAS RN: 518-34-3 | Product Number: T3321
Tetrandrine
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- (1β)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 200MG |
€45.00
|
1 | 1 | |
| 1G |
€158.00
|
Contact Us | Ships within 3-4 months after ordering |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T3321 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__3__8H__4__2N__2O__6 = 622.76 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 518-34-3 |
| Reaxys Registry Number | 79006 |
| PubChem Substance ID | 253661357 |
| Merck Index (14) | 9231 |
| MDL Number | MFCD08689909 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 218.0 to 223.0 °C |
| Specific rotation [a]20/D | +283 to +287 deg(C=1,CHCl3) |
Properties (reference)
| Melting Point | 223 °C |
| Specific Rotation | 285° (C=1,CHCl3) |
| Maximum Absorption Wavelength | 283 nm (EtOH) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | XE9350000 |
Transport Information:
| HS Number | 2934999090 |
Application
Biofilm research
Tetrandrine has been reported to inhibit Candida albicans biofilm formation.1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- 1) Effect of Tetrandrine against Candida albicans Biofilms
- Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin
- Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: Cardiovascular effects and mechanisms of action; Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives; Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases; Potential role of tetrandrine in cancer therapy (reviews)
- Herbal alkaloid tetrandrine: from an ion channel blocker to inhibitor of tumor proliferation (a review)
- Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance
- Lactoferrin-Conjugated Biodegradable Polymersome Holding Doxorubicin and Tetrandrine for Chemotherapy of Glioma Rats
- Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
Application
Tetrandrine: A Bisbenzylisoquinoline Alkaloid with Broad Pharmacological Activities
Tetrandrine is a bisbenzylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra S Moore which is a plant indigenous to main land of China that has long been used as a Chinese herb. Recently, several studies have demonstrated that tetrandrine is a calcium channel receptor antagonist. Moreover, tetrandrine exhibits broad pharmacological activities, including antihypertensive, antiarrhythmic and antitumor activities. Tetrandrine has also been shown to inhibit infection of human macrophages, the primary target of Ebola virus, and also showed therapeutic efficacy in mice. (The product is for research purpose only.)
References
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