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CAS RN: 64-77-7 | Product Number: T3690
Tolbutamide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N-(Butylcarbamoyl)-4-methylbenzenesulfonamide
- 1-Butyl-3-(4-methylphenylsulfonyl)urea
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 1G |
€ 16,00
|
Ships within 4 weeks after ordering | ≥80 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T3690 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__8N__2O__3S = 270.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 64-77-7 |
| Reaxys Registry Number | 1984428 |
| PubChem Substance ID | 354335795 |
| Merck Index (14) | 9507 |
| MDL Number | MFCD00027169 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 126.0 to 130.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 127 °C |
| Maximum Absorption Wavelength | 230 nm |
| Solubility in water | Insoluble |
| Degree of solubility in water | 109 mg/l 37 °C |
| Solubility (soluble in) | Ethanol, Chloroform |
GHS
Related Laws:
| EC Number | 200-594-3 |
| RTECS# | YS4550000 |
Transport Information:
| HS Number | 2935909099 |
Application
Tolbutamide: A First-Generation Sulfonylurea Oral Antihyperglycemic Agent
Tolbutamide is a first-generation potassium channel blocker, and a sulfonylurea oral antihyperglycemic agent. The sulfonylurea type agents reduce blood glucose levels by blocking ATP-gated K+ channels and thereby cause depolarization of the pancreatic B-cell membrane to stimulate insulin secretion. (The product is for research purpose only.)
References
- Tolbutamide (a review on the physical properties, synthesis, stability, metabolism, analysis, pharmacokinetics, and toxicity of tolbutamide)
- Tolbutamide (a review on the physical properties, methods of detection, and pharmacokinetics of tolbutamide)
PubMed Literature
Product Articles
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