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Published TCIMAIL newest issue No.199
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CAS RN: 33016-12-5 | Product Number: T3877
TN-16
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 3-(1-Anilinoethylidene)-5-benzyl-2,4-pyrrolidinedione
- 3-(1-Anilinoethylidene)-5-benzylpyrrolidine-2,4-dione
- 5-Benzyl-3-[1-(phenylamino)ethylidene]pyrrolidine-2,4-dione
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 25MG |
€116.00
|
Contact Us | 21 |
| 100MG |
€386.00
|
Contact Us | ≥40 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3877 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__9H__1__8N__2O__2 = 306.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 33016-12-5 |
| Reaxys Registry Number | 21964867 |
| PubChem Substance ID | 468592998 |
| MDL Number | MFCD02684017 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | -210.0 to -230.0 deg(C=1, CHCL3) |
Properties (reference)
| Melting Point | 185 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933790090 |
Application
TN-16: A Synthetic Inhibitor of Microtubule Polymerization
TN-16 is a synthetic inhibitor of microtubule polymerization which binds to the colchicine site.1-3) Like colchicine [C0380], TN-16 inhibits alkylation of tubulin.4)
References
- 1) Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug
- 2) Discrimination of ligands with different flexibilities resulting from the plasticity of the binding site in tubulin
- 3) Dynamic and Static Water Molecules Complement the TN16 Conformational Heterogeneity inside the Tubulin Cavity
- 4) The effect of TN-16 on the alkylation of tubulin
Product Documents (Note: Some products will not have analytical charts available.)
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