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CAS RN: 89785-84-2 | Product Number: T4106
Tazobactam Sodium
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Purity: >95.0%(T)(HPLC)
Synonyms:
- Sodium (2S,3S,5R)-3-[(1H-1,2,3-Triazol-1-yl)methyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 200MG |
€ 63,00
|
Contact Us | 6 | |
| 1G |
€ 216,00
|
Contact Us | 2 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T4106 |
Purity / Analysis Method 
|
>95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__1N__4NaO__5S = 322.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 89785-84-2 |
| Reaxys Registry Number | 6039128 |
| MDL Number | MFCD00917472 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0%(calcd.on anh.substance) |
| Water | max. 3.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 170 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 : Wear protective gloves. P284 : Wear respiratory protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | XI0191500 |
Transport Information:
| HS Number | 2941900000 |
Application
Tazobactam, A β-Lactamase Inhibitor for Antibiotics
Tazobactam [T3732] and its sodium salt, β-lactamase inhibitors, are able to inhibit enzymes (β-lactamases) produced by bacteria that destroy β-lactam antibiotics like penicillins and cephalosporins. Therefore, it can increase antibacterial activity of antibiotics and also it can expend antibacterial spectrum and reduce adverse reaction, which has broad application prospect. Many combination agents with antibiotics have been developed against Pseudomonas aeruginosa or multidrug-resistant bacteria, such as MRSA. For your reference, related products (β-lactamase inhibitors for antibiotics) are sulbactam [S0868] and 3-aminophenylboronic acid [A1281].
References
- Kinetic interactions of tazobactam with β-lactamases from all major structural classes
- Piperacillin/Tazobactam: A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential (a review)
- Ceftolozane/Tazobactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination with Activity Against Multidrug-Resistant Gram-Negative Bacilli (a review)
- New β-lactam-β-lactamase inhibitor combinations in clinical development (a review)
- β-Lactamase Inhibitors: An Update
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