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Published TCIMAIL newest issue No.198
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CAS RN: 375815-87-5 | Product Number: V0168
Varenicline Tartrate
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Purity: >95.0%(T)
Synonyms:
- 7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline (2R,3R)-2,3-Dihydroxysuccinic Acid
- 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine Tartrate
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5MG |
€67.00
|
Contact Us | 12 |
| 25MG |
€241.00
|
Contact Us | 16 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | V0168 |
| Purity / Analysis Method | >95.0%(T) |
| Molecular Formula / Molecular Weight | C__1__3H__1__3N__3·C__4H__6O__6 = 361.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 375815-87-5 |
| Reaxys Registry Number | 14347664 |
| PubChem Substance ID | 468593111 |
| MDL Number | MFCD08460603 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
| Water | max. 5.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 215 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P391 : Collect spillage. |
Related Laws:
| RTECS# | PC5072000 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
Varenicline Tartrate: A Partial Agonist/Antagonist with Affinity and Selectivity for α4β2 Nicotinic Acetylcholine Receptors
Varenicline tartrate is a partial agonist/antagonist with affinity and selectivity for α4β2 nicotinic acetylcholine receptors. Varenicline binds to α4β2 neuronal nicotinic acetylcholine receptors and stimulates receptor-mediated activity, but at a significantly lower level than nicotine. In other words, varenicline blocks the ability of nicotine to the receptors (antagonist) and thus to stimulate partially the central nervous mesolimbic dopamine system (partial agonist). In clinical, varenicline tartrate is used as an anti-smoking agent. This receptor stimulation is thought to reduce the withdrawal symptoms associated with smoking cessation and the craving for cigarettes. (The product is for research purpose only.)
References
- Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation
- Preclinical pharmacology of the α4β2 nAChR partial agonist varenicline related to effects on reward, mood and cognition
- Development and validation of RP-HPLC method for estimation of varenicline tartrate in bulk drug and tablet dosage form
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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