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CAS RN: 947669-91-2 | Product Number: W0025
WWL 70
×
Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 4'-Carbamoyl-[1,1'-biphenyl]-4-yl Methyl[3-(pyridin-4-yl)benzyl]carbamate
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 10MG |
150,00 €
|
Contact Us | ≥40 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | W0025 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__7H__2__3N__3O__3 = 437.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 947669-91-2 |
| Reaxys Registry Number | 11185410 |
| MDL Number | MFCD10567112 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2933399999 |
Application
WWL 70: A Potent and Selective Inhibitor of ABHD6
Endogenous cannabinoids, such as anandamide [A3448] and 2-arachidonoyl glycerol (2-AG) [A3490], are biologically active lipids that activate the cannabinoid receptors CB1 and CB2. Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system (ECS), which is involved in a variety of physiological processes.1) Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that for anandamide is mediated by fatty acid amide hydrolase (FAAH), and for 2-AG is thought to involve monoacylglycerol lipase (MAGL) and Abhydrolase Domain Containing 6 (ABHD6). WWL 70 is a potent and selective inhibitor of ABHD6 and has been reported to raise mice brain 2-AG levels without altering anandamide and to attenuate neuropathic pain.2-4) (The product is for research use only.)
References
- 1) An Introduction to the Endogenous Cannabinoid System
- 2) Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis
- 3) WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor independent mechanisms
- 4) WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism
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