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CAS RN: 2627-69-2 | Product Number: A2528
5-Aminoimidazole-4-carboxamide 1-β-D-Ribofuranoside
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Purity: >98.0%(HPLC)
Synonyms:
- 5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide
- Acadesine
- AICAR
Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
₹8,900.00
|
Contact Us | 26 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A2528 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__4N__4O__5 = 258.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | <0°C |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 2627-69-2 |
| Reaxys Registry Number | 38255 |
| PubChem Substance ID | 253659575 |
| Merck Index (14) | 16 |
| MDL Number | MFCD00869751 |
Specifications
| Appearance | White to Light yellow to Light red powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 21.20 to 22.00 % |
| Specific rotation [a]20/D | -61.0 to -66.0 deg(C=1、H2O) |
Properties (reference)
| Melting Point | 212 °C |
| Specific Rotation | -63° (C=1,H2O) |
| Maximum Absorption Wavelength | 265(NaOH) nm |
GHS
| Pictogram |
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| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
Acadesine (AICAR): AMP-Activated Protein Kinase Activator
5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside (Acadesine or AICAR) has been extensively used in vitro and in vivo to activate AMP-activated protein kinase (AMPK). AMPK stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy consuming functions, such as protein and cholesterol synthesis. Therefore, acadesine may have applications in treating disorders such as type 2 diabetes and Alzheimer's disease. Recently, it has been shown that acadesine induces leukemia apoptosis. (The product is for research purpose only.)
References
- 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
- J. M. Corton, J. G. Gillespie, S. A. Hawley, D. G. Hardie, Eur. J. Biochem. 1995, 229, 558.
- AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
- G. F. Merrill, E. J. Kurth, D. G. Hardie, W. W. Winder, Am. J. Physiol. 1997, 273, E1107.
- Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
- T. Hayashi, M. F. Hirshman, E. J. Kurth, W. W. Winder, L. J. Goodyear, Diabetes 1998, 47, 1369.
- Knockout of the α2 but Not α1 5'-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside- but Not Contraction-induced Glucose Uptake in Skeletal Muscle
- 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside Inhibits Cancer Cell Proliferation in Vitro and in Vivo via AMP-activated Protein Kinase
- AMP-activated protein kinase and muscle glucose uptake (a review)
- AMP-activated protein kinase: a potential player in Alzheimer's disease (a review)
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