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CAS RN: 181183-52-8 | Product Number: A3111

Almotriptan Malate

Purity: >98.0%(HPLC)
  • 3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indole Malate
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Product Number A3111
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__7H__2__5N__3O__2S·C__4H__6O__5 = 469.55  
Physical State (20 deg.C) Solid
CAS RN 181183-52-8
Related CAS RN 154323-57-6
Reaxys Registry Number 15435698
Merck Index (14) 304
MDL Number


Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 8.50 to 9.50 %
Properties (reference)
Melting Point 162 °C(dec.)
Solubility in water Soluble
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Almotriptan Malate: A Selective 5-HT1B/1D Receptor Agonist

Almotriptan malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, known as triptan. Almotriptan binds with high affinity to 5-HT1B, 5-HT1D, and 5-HT1F receptors, and has weak affinity for 5-HT1A and 5-HT7 receptors. However, almotriptan has no significant affinity at 5-HT2, 5-HT3, 5-HT4 or 5-HT6. Triptans, including almotriptan, are major advance in the treatment of migraine. The therapeutic activity of triptans in migramine can most likely to be attributed to agonist effects at 5-HT1B/1D receptors on the intracranial blood vessels. (The product is for research purpose only.)


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