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CAS RN: 181183-52-8 | Product Number: A3111
Almotriptan Malate
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Purity: >98.0%(HPLC)
Synonyms:
- 3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indole Malate
Documents:
| Size | Unit Price | Hyderabad | Chennai | Japan* | Quantity |
|---|---|---|---|---|---|
| 25MG |
₹5,000
|
2 | Contact Us | 10 |
|
| 100MG |
₹9,200
|
Contact Us | Contact Us | ≥20 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day & Chennai stocks will be dispatched in 3-6 working days.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3111 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__5N__3O__2S·C__4H__6O__5 = 469.55 |
| Physical State (20 deg.C) | Solid |
| CAS RN | 181183-52-8 |
| Related CAS RN | 154323-57-6 |
| Reaxys Registry Number | 15435698 |
| Merck Index (14) | 304 |
| MDL Number | MFCD08067740 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 8.50 to 9.50 % |
Properties (reference)
| Melting Point | 162 °C(dec.) |
| Solubility in water | Soluble |
GHS
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Application
Almotriptan Malate: A Selective 5-HT1B/1D Receptor Agonist
Almotriptan malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, known as triptan. Almotriptan binds with high affinity to 5-HT1B, 5-HT1D, and 5-HT1F receptors, and has weak affinity for 5-HT1A and 5-HT7 receptors. However, almotriptan has no significant affinity at 5-HT2, 5-HT3, 5-HT4 or 5-HT6. Triptans, including almotriptan, are major advance in the treatment of migraine. The therapeutic activity of triptans in migramine can most likely to be attributed to agonist effects at 5-HT1B/1D receptors on the intracranial blood vessels. (The product is for research purpose only.)
References
- Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine
- Almotriptan, a New Anti‐Migraine Agent: A Review
- Triptans in migraine: A comparative review of pharmacology, pharmacokinetics and efficacy
- A validated reversed phase HPLC method for the determination of process-related impurities in almotriptan malate active pharmaceutical ingredient
- A validated RP HPLC method for estimation of almotriptan malate in pharmaceutical dosage form
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