CAS RN: 68377-91-3 | Product Number: A3145
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|Purity / Analysis Method||>98.0%(T)(HPLC)|
|Molecular Formula / Molecular Weight||C__1__5H__2__1N__3O__2S__3·HCl = 407.99|
|Physical State (20 deg.C)||Solid|
|Condition to Avoid||Light Sensitive|
|Related CAS RN||68377-92-4|
|Reaxys Registry Number||10042125|
|PubChem Substance ID||354335253|
|Merck Index (14)||791|
|Appearance||White to Orange to Green powder to crystal|
|Purity(HPLC)||min. 98.0 area%|
|Purity(with Total Nitrogen)||min. 98.0 %|
|Melting Point||236 °C(dec.)|
|Solubility in water||Practically insoluble|
|Solubility (very slightly)||Methanol|
|Solubility (insoluble in)||Ethanol,Diethyl ether|
|Hazard Statements||H301 : Toxic if swallowed.
|Precautionary Statements||P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Arotinolol hydrochloride (S-596), β-adrenoceptor antagonist, shows high affinities for both β1- and β2-adrenoceptors. Reportedly, It shows a moderate affinity also for α-adrenoceptor, and the mean ratio of α:β = 1:8. In addition, its main metabolite (the 2-thiophenecarboxylic acid, AC-623) also shows affinity for β-adrenoceptors. Arotinolol is widely used in the treatment of high blood pressure. (The product is for research purpose only.)
Studies on Concurrent Alpha-and Beta-adrenoceptor Blocking Action of S-596 (Arotinolol)
Beta-receptor blocking potencies of the three newly synthesized β-adrenergic antagonists (S-596, K-351, N-696) as assessed with the radioligand binding assay method in rat cardiac muscle membrane treated with neuraminidase
Effects of S-596, a new beta-adrenoceptor blocking agent on the left ventricular performance of normal subjects during exercise
High performance liquid chromatographic determination of arotinolol and AC 623, its main metabolite, in biological samples
Enantiospecific determination of arotinolol in rat plasma by LC-MS/MS: Application to a stereoselective pharmacokinetic study
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