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CAS RN: 68377-91-3 | Product Number: A3145

Arotinolol Hydrochloride


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 5-[2-[[3-(tert-Butylamino)-2-hydroxypropyl]thio]thiazol-4-yl]thiophene-2-carboxamide Hydrochloride
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50MG
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Product Number A3145
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__5H__2__1N__3O__2S__3·HCl = 407.99  
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 68377-91-3
Related CAS RN 68377-92-4
Reaxys Registry Number 10042125
PubChem Substance ID 354335253
Merck Index (14) 791
MDL Number

MFCD00941421

Specifications
Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Properties (reference)
Melting Point 236 °C(dec.)
Solubility in water Practically insoluble
Solubility (very slightly) Methanol
Solubility (insoluble in) Ethanol,Diethyl ether
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# XM8301000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
Application
Arotinolol Hydrochloride: A β-Adrenoceptor Antagonist

Arotinolol hydrochloride (S-596), β-adrenoceptor antagonist, shows high affinities for both β1- and β2-adrenoceptors. Reportedly, It shows a moderate affinity also for α-adrenoceptor, and the mean ratio of α:β = 1:8. In addition, its main metabolite (the 2-thiophenecarboxylic acid, AC-623) also shows affinity for β-adrenoceptors. Arotinolol is widely used in the treatment of high blood pressure. (The product is for research purpose only.)

References

Studies on Concurrent Alpha-and Beta-adrenoceptor Blocking Action of S-596 (Arotinolol)

N. Takekoshi, E. Murakami, S. Matsui, H. Murakami, J. Emoto, A. Hashimoto, Jpn. Heart. J. 1983, 24, 925.

Beta-receptor blocking potencies of the three newly synthesized β-adrenergic antagonists (S-596, K-351, N-696) as assessed with the radioligand binding assay method in rat cardiac muscle membrane treated with neuraminidase

T. Nagatomo, H. Tsuchihashi, M. Sasaki, Y. Nakagawa, H. Nakahara, S. Imai, Jpn. J. Pharmacol. 1984, 34, 249.

Effects of S-596, a new beta-adrenoceptor blocking agent on the left ventricular performance of normal subjects during exercise

K. Nishida, S. Niki, K. Furukawa, C. Yamada, H. Sugihara, H. Katsume, H. Ijichi, Jpn. Heart. J. 1985, 26, 437.

High performance liquid chromatographic determination of arotinolol and AC 623, its main metabolite, in biological samples

A. Moulin, E. Maillet, D. Truffer, A. Dufour, J. Liq. Chromatogr. 1992, 15, 151.

Enantiospecific determination of arotinolol in rat plasma by LC-MS/MS: Application to a stereoselective pharmacokinetic study

Z. Qian, Y. Xu, L. Zheng, J. Zhang, Z. Hong, X. Shen, J. Pharm. Biomed. Anal. 2015, 102, 299.


PubMed Literature


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