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CAS RN: 1392399-03-9 | Product Number: B4211
BIX 01294 Trihydrochloride Hydrate
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Purity: >85.0%(N)
Synonyms:
- 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine Trihydrochloride Hydrate
Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹16,200
|
1 | 20 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B4211 |
| Purity / Analysis Method | >85.0%(N) |
| Molecular Formula / Molecular Weight | C__2__8H__3__8N__6O__2·3HCl·xH__2O = 600.03 (as Anhydrous) |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | 0-10°C |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 1392399-03-9 |
| Related CAS RN | 935693-62-2 |
| PubChem Substance ID | 253661562 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(with Total Nitrogen) | min. 85.0 %(calcd.on anh.substance) |
| Water | 2.0 to 7.0 % |
Properties (reference)
GHS
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Application
BIX-01294: A Selective Histone Methyltransferase (G9a HMTase) and G9a-Like Protein (GLP) Inhibitor
BIX-01294 is a selective inhibitor of the G9a histone methyltransferase (G9a HMTase) and G9a-like protein (GLP), and has no effect on other known HMTases. Additionally, it has been reported that BIX-01294 improves the reprogramming efficiency in neural precursor cells (NPCs) transduced with Oct3/4-Klf4 to a level comparable to transduction with all four Yamanaka factors (Oct3/4, Sox2, Klf4, and c-Myc), in generating iPS cells using Oct4 and Klf4.
References
- Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
- A combined chemical and genetic approach for the generation of induced pluripotent stem cells
- Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds
- Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
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