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CAS RN: 380843-75-4 | Product Number: B4824

Bosutinib


Purity: >95.0%(T)(HPLC)
Synonyms:
  • SKI-606
  • 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
  • 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
Documents:
250MG
₹5,500.00
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Product Number B4824
Purity / Analysis Method >95.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__6H__2__9Cl__2N__5O__3 = 530.45 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Hygroscopic
CAS RN 380843-75-4
Reaxys Registry Number 9100307
MDL Number

MFCD07367846

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 95.0 area%
Purity(Volumetric Analysis) min. 95.0 %
Water max. 5.0 %
NMR confirm to structure
Properties (reference)
Melting Point 120 °C
Solubility in water Insoluble
Degree of solubility in water 7 mg/l   25 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H320 : Causes eye irritation.
H317 : May cause an allergic skin reaction.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P273 : Avoid release to the environment.
P272 : Contaminated work clothing should not be allowed out of the workplace.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# VB0990000
Transport Information:
Application
Bosutinib: A Potent ATP-Competitive Tyrosine Kinase Inhibitor

Bosutinib (SKI-606) is a potent ATP-competitive tyrosine kinase inhibitor. Bosutinib has been reported to inhibit the Bcr-Abl kinase, which promotes chronic myeloid leukemia (CML). Inhibition of Bcr-Abl tyrosine kinase activity or signaling proteins activated by Bcr-Abl in CML cells blocks proliferation and causes apoptotic cell death. Bosutinib is also inhibits the phosphorylation of cellular signaling proteins, including Src-family kinases (Src, Lyn, and Hck) and STAT5. (The product is for research purpose only.)

References


Documents (Note: Some products will not have analytical charts available.)
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Other Documents

Life Science
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