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CAS RN: 4342-03-4 | Product Number: D3634

Dacarbazine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • DTIC
  • 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide
Documents:
1G
₹6,500
6   Contact Us
5G
₹16,700
1   2  

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Product Number D3634
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__6H__1__0N__6O = 182.19 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Light Sensitive,Heat Sensitive
CAS RN 4342-03-4
Reaxys Registry Number 521487
PubChem Substance ID 87560054
Merck Index (14) 2798
MDL Number

MFCD00057167

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Properties (reference)
Melting Point 255 °C(dec.)
GHS
Pictogram Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H351 : Suspected of causing cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# NI3950000
Transport Information:
Application
Dacarbazine: A Triazene Alkylating Agent with Antitumor and Mutagenic Properties

Dacarbazine (DTIC) is a triazene alkylating agent with antitumor and mutagenic properties, such as temozolomide [T2744]. DTIC is a prodrug that is metabolized to 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (MTIC) which serves to transport a methylating agent (diazomethane) to the O 6 position of guanine within the major groove of DNA that generate base/base mismatches with cytosine and with thymine. These adduct lead to cell death, or if the cell survives, provoke mutations in DNA helix. DTIC is used for the treatment of melanoma. (The product is for research purpose only.)

References


PubMed Literature


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