Doxepin Hydrochloride: A Monoamine Reuptake Inhibitor with a Wide Range of Pharmacological Properties
Doxepin hydrochloride has a wide range of pharmacological properties including an antinoradrenergic property. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H
1 and H
2 receptors. Doxepin hydrochloride is a family of tricyclic antidepressant agents such as amitriptyline hydrochloride [
A0908] and imipramine hydrochloride. (The product is for research purpose only.)