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CAS RN: 74050-98-9 | Product Number: K0051

Ketanserin

Purity: >98.0%(T)(HPLC)

Synonyms:

3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione

Product Documents:

Size	Unit Price	Hyderabad	Japan*	Quantity
200MG	₹4,100.00	1	20
1G	₹10,500.00	Contact Us	17

*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

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General Information plus

Specifications & Properties plus

Specifications

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %
Melting point	231.0 to 235.0 °C
NMR	confirm to structure

Properties (reference)

Melting Point	233 °C
Solubility in water	Insoluble
Degree of solubility in water	10 mg/l
Solubility (slightly sol. in)	Dimethylformamide

Safety & Regulations plus

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H302 : Harmful if swallowed.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.

Related Laws:

RTECS#

VA1411190

Transport Information:

Applications & Literature plus

Application

Ketanserin: A Selective 5-HT2a Receptor Antagonist with Weak α1-Adrenoceptor Antagonistic Activity

Ketanserin is a selective 5-HT_2a receptor antagonist. 5-HT receptors can be divided into some receptor subtypes. Ketanserin is used for discrimination between 5-HT receptor subtypes. Ketanserin also has weak α₁-adrenoceptor antagonistic activity which may explain its antihypertensive mechanism of action. Ketanserin inhibits the effects of serotonin on platelets, and inhibits vasoconstriction caused by the catecholamine. (The product is for research purpose only.)

References

Ketanserin: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in hypertension and peripheral vascular disease
- R. N. Brogden, E. M. Sorkin, Drugs 1990, 40, 903.
Ketanserin and ritanserin discriminate between recombinant human 5-HT_1Dα and 5-HT_1Dβ receptor subtypes
- J. M. Zgombick, L. E. Schechter, S. A. Kucharewicz, R. L. Weinshank, T. A. Branchek, Eur. J. Pharmacol. Mol. Pharmacol. 1995, 291, 9.
Molecular modeling of serotonin, ketanserin, ritanserin and their 5-HT_2C receptor interactions
- K. Kristiansen, S. G. Dahl, Eur. J. Pharmacol. 1996, 306, 195.
Ketanserin and spiperone as templates for novel serotonin 5-HT_2A antagonists (a review)
- R. A. Glennon, K. Metwally, M. Dukat, A. M. Ismaiel, J. De Los Angeles, J. Herndon, M. Teitler, N. Khorana, Curr. Top. Med. Chem. 2002, 2, 539.
Serotoninergic mechanisms in hypertension. Focus on the effects of ketanserin (a review)
- P. Vanhoutte, A. Amery, W. Birkenhäger, A. Breckenridge, F. Bühler, A. Distler, J. Dormandy, A. Doyle, E. Frohlich, L. Hansson, Hypertension 1988, 11, 111.

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Product Categories

Life Science

Chemicals by Class

6-Membered Heterocyclic Compounds [Chemical Structural Class]

Pyrimidines [Chemical Structural Class]

Quinazolines [Chemical Structural Class]

Life Science

Chemicals by Class

6-Membered Heterocyclic Compounds [Chemical Structural Class]

Pyrimidines [Chemical Structural Class]

Quinazolines [Chemical Structural Class]

Product Number	K0051
Purity / Analysis Method	>98.0%(T)(HPLC)
Molecular Formula / Molecular Weight	C__2__2H__2__2FN__3O__3 = 395.43
Physical State (20 deg.C)	Solid
Storage Temperature	Refrigerated (0-10°C)
Condition to Avoid	Heat Sensitive
Packaging and Container	200MG-Glass Bottle with Plastic Insert (View image)
CAS RN	74050-98-9
Reaxys Registry Number	4913068
PubChem Substance ID	253661148
Merck Index (14)	5296
MDL Number	MFCD00083392

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CAS RN: 74050-98-9 | Product Number: K0051