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CAS RN: 148553-50-8 | Product Number: P2840

Pregabalin


Purity: >98.0%(T)
Synonyms:
  • (S)-3-(Aminomethyl)-5-methylhexanoic Acid
Documents:
10MG
₹2,870.00
2   ≥80 
50MG
₹8,610.00
Contact Us ≥100 

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Product Number P2840
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__8H__1__7NO__2 = 159.23 
Physical State (20 deg.C) Solid
CAS RN 148553-50-8
Reaxys Registry Number 8404778
PubChem Substance ID 468592747
MDL Number

MFCD00917044

Specifications
Appearance White to Almost white powder to crystal
Purity(Nonaqueous Titration) min. 98.0 %
Specific rotation +10.0 to +12.0 deg (C=1, Water)
NMR confirm to structure
Properties (reference)
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# MO6452000
Transport Information:
Application
Pregabalin: A Potent Ligand for the α2δ Subunit of Voltage-Gated Ca2+ Channels in the Central Nervous System

Pregabalin is one of the analogs of γ-aminobutyric acid (GABA) [A0282], but it works as a potent ligand for the α2δ subunit of voltage-gated Ca2+ channels in the central nervous system that exhibits potent anxiolytic, analgesic, and anticonvulsant properties in a range of animal models. Pregabalin binds potently and selectively to the α2δ subunit of "hyper-excited" voltage-gated calcium channels (VGCCs). The binding of pregabalin to VGCCs changes their conformation, reducing Ca2+ influx at nerve terminals. Consequently, pregabalin modulates the release of excitatory neurotransmitters in "hyper-excited" neurons, restoring them to normal physiological state. This mechanism of action is believed to confer on pregabalin its anxiolytic, analgesic, and anticonvulsant properties. (The product is for research purpose only.)

References


Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Other Documents

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